Specshell ApS designs, develops, and manufactures real-time process analytical technologies (PAT) that provides actionable data for bioprocess monitoring. Specshell’s patented technology allows the user to monitor key component concentrations directly in the process stream both for quality control and optimization.
A number of other process analytical technologies are available in the market (NIR, FTIR or Raman) have potential for process monitoring in some situations, but the majority of technologies based on conventional in-line spectroscopic techniques are yet to provide an easy-to-use, industrially robust unit with a high degree of accuracy in a process setting. Many offerings require considerable user input to calibration and set-up the instrument, which are time intensive and require considerable expertise and additional equipment to establish. Specshell’s instruments are designed and installed with the user in mind and deliver meaningful data from the first batch upon installation
LIVE PROCESS MONITORING
Specshell’s analytical instruments record the inline reflected spectra from the process and through a set of unique multivariate calibration complex, tailored to each specific application, they are able to determine and provide a full profiling of the key molecules present in the analyzed slurries or liquids. Specshell’s instruments do not try to outperform conventional chromatographic techniques such as HPLC or GC-MS for error and detection limits, but give the greater benefit of having online data generation over the course of the whole process tells you much more. Operators can even better decide when to sample their process based on SIBA or ZYMON outputs, increasing your staff and labs efficiency!
INLINE PROCESS ANALYSIS
Specshell has designed all of the analytical instruments in order to avoid tedious sample filtration and processing, providing the user with a stand-alone inline analytical device that requires no operator intervention for the monitoring of the process. The technology only measures dissolved species, as it is able to neglect solid particles. The device is connected to the process in a closed sample loop, placing the slurry in contact the advanced optics unit and diamond sample plate. The Mid-infrared IR beam will create an evanescent wave when interacting with the diamond that interacts with only the dissolved components of the slurry before the unabsorbed portion of the IR beam is sent to the detector.
ADVANCED OPTICAL TECHNOLOGY
Specshell’s analytical solutions operate in the Mid infrared area (MIR) where the dissolved components in contact with the diamond will present a unique fingerprint of absorption. From these absorption fingerprints, or spectra, we can extract very detailed information about the key molecules of interest. This information in turn is used in Specshell’s advanced chemometric models to predict the concentrations in real-time. Thus, these devices provide very accurate measurements real-time measurements from the process. In contrast, system utilizing Near infrared (NIR) technologies produce spectra which capture less of detail with regards to the dissolved components in the process liquid, effectively they can’t distinguish between molecules that are very similar, like simple sugars for instance. This means that predictive models based on NIR are uncertain and can provide incorrect information on the presence and concentration of the molecules of interest, limiting their application in industrial processes.
INDUSTRIAL ROBUST TECHNOLOGY
Specshell technology has been developed to be industrial robust, and perform optimally, even in the harsh conditions of an industrial setting. Manufactured from robust, food-grade materials, when placed in the right place, SIBA and ZYMON will work optimally year-round.
Even though Specshell’s system are state-of-the-art inline analytical systems, providing high degrees of analytical sensitivity, they has been designed in a way that they only need to be incorporated into the standard caustics CIP schedule. Fouling is minimized by Specshell’s patented self-cleaning technology, providing users with a maintenance free solution for 24/7 monitoring. In ZYMON case, our system can even be used to assess the effectiveness of the caustic CIP cycle by monitoring its chemical composition inline.
Specshell’s technologies have been developed to cope with processes that handle liquids across a wide temperature and pressure range, as commonly encountered in a brewery or bioprocess facility. Inline liquid temperatures of 5-90°C and pressures up to 3 bar are easily handled without worry of damage to the instrument.